British Air Force Typhoon FGR4s have joined forces with France's air force in a joint strike on an hidden munitions depot in Syrian territory operated by the IS group, per a report from the UK's MoD.
The location, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was positioned in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft used Paveway IV guided bombs to strike a several access tunnels leading to the depot... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the strike late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The British jets were backed up by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as the so-called Islamic State - enforced extremist governance over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This operation underscores our UK leadership, and commitment to work closely with allied nations, to eliminate any revival of IS and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary said.
RAF aircraft have performed overwatch operations over Syria to "deter any attempted resurgence" of IS subsequent to its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank the personnel of British forces involved in this operation for their skill and their courage," Healey added. "They were among a great many British personnel on duty over the festive period. This mission, to remove dangerous terrorists who threaten our safety, highlights how UK forces are always on standby, throughout the year, protecting the UK domestically and strong abroad."
Last December, the American forces conducted what it termed a "massive strike" against Daesh sites in the country, after an attack claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The UN reports Daesh still has roughly 5-7 thousand militants in Iraq and Syria.